Development and Validation of Spectrophotometric Methods for the Determination of Rasagiline in Pharmaceutical Preparations
Joint Authors
Kepekci Tekkeli, Serife Evrim
Önal, Armağan
Bahadori, Fatemeh
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study presents three simple, rapid, and accurate spectrophotometric methods for the determination of Rasagiline (RSG) in pharmaceutical preparations.
The determination procedures depend on the reaction of RSG with chloranilic acid for method A, tetrachloro-1,4-benzoquinone for method B, and 7,7,8,8-tetracyanoquinodimethane for method C.
The colored products were quantitated spectrophotometrically at 524, 535, and 843 nm for methods A, B, and C, respectively.
Different variables affecting the reaction were optimized.
Linearity ranges of the methods with good correlation coefficients (0.9988–0.9996) were observed as 25–300 µg mL−1, 25–350 µg mL−1, and 50–500 µg mL−1 for methods A, B, and C, respectively.
The formation of products takes place through different mechanisms.
The sites of interaction were confirmed by elemental analysis using IR and 1H-NMR spectroscopy.
The validation of the methods was carried out in terms of specificity, linearity, accuracy, precision, robustness, limit of detection, and limit of quantitation.
No interference was observed from concomitants usually present in dosage forms.
The methods were applied successfully to the determination of RSG in pharmaceutical preparations.
American Psychological Association (APA)
Kepekci Tekkeli, Serife Evrim& Önal, Armağan& Bahadori, Fatemeh. 2013. Development and Validation of Spectrophotometric Methods for the Determination of Rasagiline in Pharmaceutical Preparations. Journal of Spectroscopy،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508125
Modern Language Association (MLA)
Kepekci Tekkeli, Serife Evrim…[et al.]. Development and Validation of Spectrophotometric Methods for the Determination of Rasagiline in Pharmaceutical Preparations. Journal of Spectroscopy No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-508125
American Medical Association (AMA)
Kepekci Tekkeli, Serife Evrim& Önal, Armağan& Bahadori, Fatemeh. Development and Validation of Spectrophotometric Methods for the Determination of Rasagiline in Pharmaceutical Preparations. Journal of Spectroscopy. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508125