Nrf2 Is Crucial to Graft Survival in a Rodent Model of Heart Transplantation
Joint Authors
Zhang, Donna D.
Qiu, Quan
Whitman, Samantha A.
Wang, Huihui
Wu, Wei
Fang, Deyu
Lian, Fangru
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Currently, the sole treatment option for patients with heart failure is transplantation.
The battle of prolonging graft survival and modulating innate and adaptive immune responses is still being waged in the clinic and in research labs.
The transcription factor Nrf2 controls major cell survival pathways and is central to moderating inflammation and immune responses.
In this study the effect of Nrf2 levels in host recipient C57BL/6 mice on Balb/c allogeneic graft survival was examined.
Importantly, Nrf2−/− recipient mice could not support the graft for longer than 7.5 days on average, whereas activation of Nrf2 by sulforaphane in Nrf2+/+ hosts prolonged graft survival to 13 days.
Several immune cells in the spleen of recipient mice were unchanged; however, CD11b+ macrophages were significantly increased in Nrf2−/− mice.
In addition, IL-17 mRNA levels were elevated in grafts transplanted into Nrf2−/− mice.
Although Nrf2 appears to play a crucial role in graft survival, the exact mechanism is yet to be fully understood.
American Psychological Association (APA)
Wu, Wei& Qiu, Quan& Wang, Huihui& Whitman, Samantha A.& Fang, Deyu& Lian, Fangru…[et al.]. 2013. Nrf2 Is Crucial to Graft Survival in a Rodent Model of Heart Transplantation. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-508140
Modern Language Association (MLA)
Wu, Wei…[et al.]. Nrf2 Is Crucial to Graft Survival in a Rodent Model of Heart Transplantation. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-508140
American Medical Association (AMA)
Wu, Wei& Qiu, Quan& Wang, Huihui& Whitman, Samantha A.& Fang, Deyu& Lian, Fangru…[et al.]. Nrf2 Is Crucial to Graft Survival in a Rodent Model of Heart Transplantation. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-508140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508140