Use of Foscarnet Therapy for EBV Infection following Control of PTLD with Enhancement of Cellular Immunity in a Lung-Transplant Recipient
Joint Authors
Forrester, Kevin
Afshar, Kamyar
Rao, A. Purush
Ganesh, Sivagini
Patel, Vipul
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-03
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Posttransplant lymphoproliferative disorder (PTLD) is a serious complication following solid organ transplantation with an annual incidence rate of 3–5% in lung-transplant recipients.
Pathogenesis indicates a strong association with functional over-immunosuppression and EBV infection.
Clinical improvement is generally observed with reduction in immunosuppression intensity alone.
We present a case of a 24-year-old woman with EBV-associated PTLD following lung transplant where decreasing the immunosuppression improved PTLD but was ineffective against controlling the EBV infection.
Foscarnet in combination with immunoglobulins was successfully administered to cause a remission of the EBV infection.
This is the second case reported of a persistent EBV infection after reducing immunosuppression levels and evidence of PTLD remission that required foscarnet for EBV infection control.
American Psychological Association (APA)
Afshar, Kamyar& Rao, A. Purush& Patel, Vipul& Forrester, Kevin& Ganesh, Sivagini. 2011. Use of Foscarnet Therapy for EBV Infection following Control of PTLD with Enhancement of Cellular Immunity in a Lung-Transplant Recipient. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-508163
Modern Language Association (MLA)
Afshar, Kamyar…[et al.]. Use of Foscarnet Therapy for EBV Infection following Control of PTLD with Enhancement of Cellular Immunity in a Lung-Transplant Recipient. Journal of Transplantation No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-508163
American Medical Association (AMA)
Afshar, Kamyar& Rao, A. Purush& Patel, Vipul& Forrester, Kevin& Ganesh, Sivagini. Use of Foscarnet Therapy for EBV Infection following Control of PTLD with Enhancement of Cellular Immunity in a Lung-Transplant Recipient. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-508163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508163