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H2AX Phosphorylation : Its Role in DNA Damage Response and Cancer Therapy
Joint Authors
Skladanowski, Andrzej
Podhorecka, Monika
Bozko, Przemyslaw
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Double-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death.
Various physical, chemical, and biological factors are involved in DSB induction.
Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism developed to detect and repair DNA damage.
The formation of DSBs triggers activation of many factors, including phosphorylation of the histone variant H2AX, producing γH2AX.
Phosphorylation of H2AX plays a key role in DDR and is required for the assembly of DNA repair proteins at the sites containing damaged chromatin as well as for activation of checkpoints proteins which arrest the cell cycle progression.
In general, analysis of γH2AX expression can be used to detect the genotoxic effect of different toxic substances.
When applied to clinical samples from cancer patients, evaluation of γH2AX levels may allow not only to monitor the efficiency of anticancer treatment but also to predict of tumor cell sensitivity to DNA damaging anticancer agents and toxicity of anticancer treatment toward normal cells.
American Psychological Association (APA)
Podhorecka, Monika& Skladanowski, Andrzej& Bozko, Przemyslaw. 2010. H2AX Phosphorylation : Its Role in DNA Damage Response and Cancer Therapy. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-508184
Modern Language Association (MLA)
Podhorecka, Monika…[et al.]. H2AX Phosphorylation : Its Role in DNA Damage Response and Cancer Therapy. Journal of Nucleic Acids No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-508184
American Medical Association (AMA)
Podhorecka, Monika& Skladanowski, Andrzej& Bozko, Przemyslaw. H2AX Phosphorylation : Its Role in DNA Damage Response and Cancer Therapy. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-508184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508184