IP3 Receptors, Mitochondria, and Ca2+ Signaling : Implications for Aging
Joint Authors
Missiaen, Ludwig
De Smedt, Humbert
Bultynck, Geert
Parys, Jan B.
Decuypere, Jean-Paul
Monaco, Giovanni
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-08
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
The tight interplay between endoplasmic-reticulum-(ER-) and mitochondria-mediated Ca2+ signaling is a key determinant of cellular health and cellular fate through the control of apoptosis and autophagy.
Proteins that prevent or promote apoptosis and autophagy can affect intracellular Ca2+ dynamics and homeostasis through binding and modulation of the intracellular Ca2+-release and Ca2+-uptake mechanisms.
During aging, oxidative stress becomes an additional factor that affects ER and mitochondrial function and thus their role in Ca2+ signaling.
Importantly, mitochondrial dysfunction and sustained mitochondrial damage are likely to underlie part of the aging process.
In this paper, we will discuss the different mechanisms that control intracellular Ca2+ signaling with respect to apoptosis and autophagy and review how these processes are affected during aging through accumulation of reactive oxygen species.
American Psychological Association (APA)
Decuypere, Jean-Paul& Monaco, Giovanni& Missiaen, Ludwig& De Smedt, Humbert& Parys, Jan B.& Bultynck, Geert. 2011. IP3 Receptors, Mitochondria, and Ca2+ Signaling : Implications for Aging. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-508187
Modern Language Association (MLA)
Decuypere, Jean-Paul…[et al.]. IP3 Receptors, Mitochondria, and Ca2+ Signaling : Implications for Aging. Journal of Aging Research No. 2011 (2011), pp.1-20.
https://search.emarefa.net/detail/BIM-508187
American Medical Association (AMA)
Decuypere, Jean-Paul& Monaco, Giovanni& Missiaen, Ludwig& De Smedt, Humbert& Parys, Jan B.& Bultynck, Geert. IP3 Receptors, Mitochondria, and Ca2+ Signaling : Implications for Aging. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-508187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508187