Pathogenesis of the Metabolic Syndrome : Insights from Monogenic Disorders
Joint Authors
Murphy, Rinki
Carroll, Richard W.
Krebs, Jeremy D.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-21
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Identifying rare human metabolic disorders that result from a single-gene defect has not only enabled improved diagnostic and clinical management of such patients, but also has resulted in key biological insights into the pathophysiology of the increasingly prevalent metabolic syndrome.
Insulin resistance and type 2 diabetes are linked to obesity and driven by excess caloric intake and reduced physical activity.
However, key events in the causation of the metabolic syndrome are difficult to disentangle from compensatory effects and epiphenomena.
This review provides an overview of three types of human monogenic disorders that result in (1) severe, non-syndromic obesity, (2) pancreatic beta cell forms of early-onset diabetes, and (3) severe insulin resistance.
In these patients with single-gene defects causing their exaggerated metabolic disorder, the primary defect is known.
The lessons they provide for current understanding of the molecular pathogenesis of the common metabolic syndrome are highlighted.
American Psychological Association (APA)
Murphy, Rinki& Carroll, Richard W.& Krebs, Jeremy D.. 2013. Pathogenesis of the Metabolic Syndrome : Insights from Monogenic Disorders. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-508192
Modern Language Association (MLA)
Murphy, Rinki…[et al.]. Pathogenesis of the Metabolic Syndrome : Insights from Monogenic Disorders. Mediators of Inflammation No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-508192
American Medical Association (AMA)
Murphy, Rinki& Carroll, Richard W.& Krebs, Jeremy D.. Pathogenesis of the Metabolic Syndrome : Insights from Monogenic Disorders. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-508192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508192