Blood-Brain Barrier Integrity and Breast Cancer Metastasis to the Brain
Joint Authors
Wang, Lili
Avraham, Hava Karsenty
Avraham, Shalom
Sy, Christopher
Arshad, Farheen
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Brain metastasis, an important cause of cancer morbidity and mortality, occurs in at least 30% of patients with breast cancer.
A key event of brain metastasis is the migration of cancer cells through the blood-brain barrier (BBB).
Although preventing brain metastasis is immensely important for survival, very little is known about the early stage of transmigration and the molecular mechanisms of breast tumor cells penetrating the BBB.
The brain endothelium plays an important role in brain metastasis, although the mechanisms are not clear.
Brain Microvascular Endothelial Cells (BMECs) are the major cellular constituent of the BBB.
BMECs are joined together by intercellular tight junctions (TJs) that are responsible for acquisition of highly selective permeability.
Failure of the BBB is a critical event in the development and progression of several diseases that affect the CNS, including brain tumor metastasis development.
Here, we have delineated the mechanisms of BBB impairment and breast cancer metastasis to the brain.
Understanding the molecular mediators that cause changes in the BBB should lead to better strategies for effective treatment modalities targeted to inhibition of brain tumors.
American Psychological Association (APA)
Arshad, Farheen& Wang, Lili& Sy, Christopher& Avraham, Shalom& Avraham, Hava Karsenty. 2010. Blood-Brain Barrier Integrity and Breast Cancer Metastasis to the Brain. Pathology Research International،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-508223
Modern Language Association (MLA)
Arshad, Farheen…[et al.]. Blood-Brain Barrier Integrity and Breast Cancer Metastasis to the Brain. Pathology Research International No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-508223
American Medical Association (AMA)
Arshad, Farheen& Wang, Lili& Sy, Christopher& Avraham, Shalom& Avraham, Hava Karsenty. Blood-Brain Barrier Integrity and Breast Cancer Metastasis to the Brain. Pathology Research International. 2010. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-508223
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508223