Pathobiology of Hodgkin Lymphoma
Joint Authors
Sapienza, Maria Rosaria
Gazzola, Anna
Righi, Simona
Piccaluga, Pier Paolo
Sagramoso-Sacchetti, Carlo A.
Tripodo, Claudio
Sista, Maria Teresa
Rossi, Maura
Mannu, Claudia
Laginestra, Maria Antonella
Sabattini, Elena
Agostinelli, Claudio
Bacci, Francesco
Pileri, Stefano A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-22
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Despite its well-known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics, histogenesis, and possible mechanisms of lymphomagenesis.
There is complete consensus on the B-cell derivation of the tumor in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients.
The REAL/WHO classification recognizes a basic distinction between lymphocyte predominance HL (LP-HL) and classic HL (cHL), reflecting the differences in clinical presentation and behavior, morphology, phenotype, and molecular features.
cHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, with mixed cellularity, and lymphocyte depleted.
The borders between cHL and anaplastic large-cell lymphoma have become sharper, whereas those between LP-HL and T-cell-rich B-cell lymphoma remain ill defined.
Treatments adjusted to the pathobiological characteristics of the tumor in at-risk patients have been proposed and are on the way to being applied.
American Psychological Association (APA)
Piccaluga, Pier Paolo& Agostinelli, Claudio& Gazzola, Anna& Tripodo, Claudio& Bacci, Francesco& Sabattini, Elena…[et al.]. 2010. Pathobiology of Hodgkin Lymphoma. Advances in Hematology،Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-508271
Modern Language Association (MLA)
Piccaluga, Pier Paolo…[et al.]. Pathobiology of Hodgkin Lymphoma. Advances in Hematology No. 2011 (2011), pp.1-18.
https://search.emarefa.net/detail/BIM-508271
American Medical Association (AMA)
Piccaluga, Pier Paolo& Agostinelli, Claudio& Gazzola, Anna& Tripodo, Claudio& Bacci, Francesco& Sabattini, Elena…[et al.]. Pathobiology of Hodgkin Lymphoma. Advances in Hematology. 2010. Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-508271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508271