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Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury Model
Joint Authors
Wang, Hsin-Ying
Lue, June-Horng
Lin, Tzu-Yu
Chen, Seu-Hwa
Lin, Chi-Te
Tsai, Yi-Ju
Source
Anesthesiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study investigates the effects of lidocaine pre-emptive treatment on neuropathic pain behavior, injury discharges of nerves, neuropeptide Y (NPY) and c-Fos expression in the cuneate nucleus (CN) after median nerve chronic constriction injury (CCI).
Behavior tests demonstrated that the pre-emptive lidocaine treatment dose dependently delayed and attenuated the development of mechanical allodynia within a 28-day period.
Electrophysiological recording was used to examine the changes in injury discharges of the nerves.
An increase in frequency of injury discharges was observed and peaked at postelectrical stimulation stage in the presaline group, which was suppressed by lidocaine pre-emptive treatment in a dose-dependent manner.
Lidocaine pretreatment also reduced the number of injury-induced NPY-like immunoreactive (NPY-LI) fibers and c-Fos-LI neurons within the CN in a dose-dependent manner.
Furthermore, the mean number of c-Fos-LI neurons in the CN was significantly correlated to the NPY reduction level and the sign of mechanical allodynia following CCI.
American Psychological Association (APA)
Lin, Chi-Te& Tsai, Yi-Ju& Wang, Hsin-Ying& Chen, Seu-Hwa& Lin, Tzu-Yu& Lue, June-Horng. 2011. Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury Model. Anesthesiology Research and Practice،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-508312
Modern Language Association (MLA)
Lin, Chi-Te…[et al.]. Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury Model. Anesthesiology Research and Practice No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-508312
American Medical Association (AMA)
Lin, Chi-Te& Tsai, Yi-Ju& Wang, Hsin-Ying& Chen, Seu-Hwa& Lin, Tzu-Yu& Lue, June-Horng. Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury Model. Anesthesiology Research and Practice. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-508312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508312