OXavidin for Tissue Targeting Biotinylated Therapeutics
Joint Authors
De Santis, Rita
Albertoni, Claudio
Salvatori, Giovanni
Leoni, Barbara
Petronzelli, Fiorella
Paganelli, Giovanni
Verdoliva, Antonio
D'Alessio, Valeria
Nuzzolo, Carlo Antonio
Nucera, Eleonora
Rosi, Antonio
Carminati, Paolo
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Avidin is a glycoprotein from hen egg white that binds biotin with very high affinity.
Here we describe OXavidin, a product containing aldehyde groups, obtained by ligand-assisted sugar oxidation of avidin by sodium periodate.
OXavidin chemically reacts with cellular and tissue proteins through Schiff's base formation thus residing in tissues for weeks while preserving the biotin binding capacity.
The long tissue residence of OXavidin as well as that of OXavidin/biotinylated agent complex occurs in normal and neoplastic tissues and immunohistochemistry shows a strong and homogenous stromal localization.
Once localized in tissue/tumor, OXavidin becomes an “artificial receptor” for intravenous injected biotin allowing tumor targeting with biotinylated therapeutics like radioisotopes or toxins.
Moreover, present data also suggest that OXavidin might be useful for the homing of biotinylated cells.
Overall, OXavidin exhibits a remarkable potential for many different therapeutic applications.
American Psychological Association (APA)
De Santis, Rita& Albertoni, Claudio& Rosi, Antonio& Leoni, Barbara& Petronzelli, Fiorella& D'Alessio, Valeria…[et al.]. 2010. OXavidin for Tissue Targeting Biotinylated Therapeutics. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-508314
Modern Language Association (MLA)
De Santis, Rita…[et al.]. OXavidin for Tissue Targeting Biotinylated Therapeutics. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-508314
American Medical Association (AMA)
De Santis, Rita& Albertoni, Claudio& Rosi, Antonio& Leoni, Barbara& Petronzelli, Fiorella& D'Alessio, Valeria…[et al.]. OXavidin for Tissue Targeting Biotinylated Therapeutics. Journal of Biomedicine and Biotechnology. 2010. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-508314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508314