Transcription Regulation of E-Cadherin by Zinc Finger E-Box Binding Homeobox Proteins in Solid Tumors
Joint Authors
Wong, Thian-Sze
Gao, Wei
Chan, Jimmy Yu-Wai
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Downregulation of E-cadherin in solid tumors with regional migration and systematic metastasis is well recognized.
In view of its significance in tumorigenesis and solid cancer progression, studies on the regulatory mechanisms are important for the development of target treatment and prediction of clinical behavior for cancer patients.
The vertebrate zinc finger E-box binding homeobox (ZEB) protein family comprises 2 major members: ZEB1 and ZEB2.
Both contain the motif for specific binding to multiple enhancer boxes (E-boxes) located within the short-range transcription regulatory regions of the E-cadherin gene.
Binding of ZEB1 and ZEB2 to the spaced E-cadherin E-boxes has been implicated in the regulation of E-cadherin expression in multiple human cancers.
The widespread functions of ZEB proteins in human malignancies indicate their significance.
Given the significance of E-cadherin in the solid tumors, a deeper understanding of the functional role of ZEB proteins in solid tumors could provide insights in the design of target therapy against the migratory nature of solid cancers.
American Psychological Association (APA)
Wong, Thian-Sze& Gao, Wei& Chan, Jimmy Yu-Wai. 2014. Transcription Regulation of E-Cadherin by Zinc Finger E-Box Binding Homeobox Proteins in Solid Tumors. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-508323
Modern Language Association (MLA)
Wong, Thian-Sze…[et al.]. Transcription Regulation of E-Cadherin by Zinc Finger E-Box Binding Homeobox Proteins in Solid Tumors. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-508323
American Medical Association (AMA)
Wong, Thian-Sze& Gao, Wei& Chan, Jimmy Yu-Wai. Transcription Regulation of E-Cadherin by Zinc Finger E-Box Binding Homeobox Proteins in Solid Tumors. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-508323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508323