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Review of Salvage Therapy for Biochemically Recurrent Prostate Cancer : The Role of Imaging and Rationale for Systemic Salvage Targeted Anti-Prostate-Specific Membrane Antigen Radioimmunotherapy
Joint Authors
Tagawa, Scott T.
Osborne, Joseph R.
Akhtar, Naveed H.
Kosuri, Satyajit
Smith, Michael J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Despite local therapy with curative intent, approximately 30% of men suffer from biochemical relapse.
Though some of these PSA relapses are not life threatening, many men eventually progress to metastatic disease and die of prostate cancer.
Local therapy is an option for some men, but many have progression of disease following local salvage attempts.
One significant issue in this setting is the lack of reliable imaging biomarkers to guide the use of local salvage therapy, as the likely reason for a low cure rate is the presence of undetected micrometastatic disease outside of the prostate/prostate bed.
Androgen deprivation therapy is a cornerstone of therapy in the salvage setting.
While subsets may benefit in terms of delay in time to metastatic disease and/or death, research is ongoing to improve salvage systemic therapy.
Prostate-specific membrane antigen (PSMA) is highly overexpressed by the majority of prostate cancers.
While initial methods of exploiting PSMA’s high and selective expression were suboptimal, additional work in both imaging and therapeutics is progressing.
Salvage therapy and imaging modalities in this setting are briefly reviewed, and the rationale for PSMA-based systemic salvage radioimmunotherapy is described.
American Psychological Association (APA)
Kosuri, Satyajit& Akhtar, Naveed H.& Smith, Michael J.& Osborne, Joseph R.& Tagawa, Scott T.. 2012. Review of Salvage Therapy for Biochemically Recurrent Prostate Cancer : The Role of Imaging and Rationale for Systemic Salvage Targeted Anti-Prostate-Specific Membrane Antigen Radioimmunotherapy. Advances in Urology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-508332
Modern Language Association (MLA)
Kosuri, Satyajit…[et al.]. Review of Salvage Therapy for Biochemically Recurrent Prostate Cancer : The Role of Imaging and Rationale for Systemic Salvage Targeted Anti-Prostate-Specific Membrane Antigen Radioimmunotherapy. Advances in Urology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-508332
American Medical Association (AMA)
Kosuri, Satyajit& Akhtar, Naveed H.& Smith, Michael J.& Osborne, Joseph R.& Tagawa, Scott T.. Review of Salvage Therapy for Biochemically Recurrent Prostate Cancer : The Role of Imaging and Rationale for Systemic Salvage Targeted Anti-Prostate-Specific Membrane Antigen Radioimmunotherapy. Advances in Urology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-508332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508332