Autism : A “Critical Period” Disorder?
Joint Authors
LeBlanc, Jocelyn J.
Fagiolini, Michela
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-03
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Cortical circuits in the brain are refined by experience during critical periods early in postnatal life.
Critical periods are regulated by the balance of excitatory and inhibitory (E/I) neurotransmission in the brain during development.
There is now increasing evidence of E/I imbalance in autism, a complex genetic neurodevelopmental disorder diagnosed by abnormal socialization, impaired communication, and repetitive behaviors or restricted interests.
The underlying cause is still largely unknown and there is no fully effective treatment or cure.
We propose that alteration of the expression and/or timing of critical period circuit refinement in primary sensory brain areas may significantly contribute to autistic phenotypes, including cognitive and behavioral impairments.
Dissection of the cellular and molecular mechanisms governing well-established critical periods represents a powerful tool to identify new potential therapeutic targets to restore normal plasticity and function in affected neuronal circuits.
American Psychological Association (APA)
LeBlanc, Jocelyn J.& Fagiolini, Michela. 2011. Autism : A “Critical Period” Disorder?. Neural Plasticity،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-508333
Modern Language Association (MLA)
LeBlanc, Jocelyn J.& Fagiolini, Michela. Autism : A “Critical Period” Disorder?. Neural Plasticity No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-508333
American Medical Association (AMA)
LeBlanc, Jocelyn J.& Fagiolini, Michela. Autism : A “Critical Period” Disorder?. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-508333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508333