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Modeling the Effects of Relapse in the Transmission Dynamics of Malaria Parasites
Joint Authors
Gomes, M. Gabriela M.
Águas, Ricardo
Ferreira, Marcelo U.
Source
Journal of Parasitology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Often regarded as “benign,” Plasmodium vivax infections lay in the shadows of the much more virulent P.
falciparum infections.
However, about 1.98 billion people are at risk of both parasites worldwide, stressing the need to understand the epidemiology of Plasmodium vivax, particularly under the scope of decreasing P.
falciparum prevalence and ecological interactions between both species.
Two epidemiological observations put the dynamics of both species into perspective: (1) ACT campaigns have had a greater impact on P.
falciparum prevalence.
(2) Complete clinical immunity is attained at younger ages for P.
vivax, under similar infection rates.
We systematically compared two mathematical models of transmission for both Plasmodium species.
Simulations suggest that an ACT therapy combined with a hypnozoite killing drug would eliminate both species.
However, P.
vivax elimination is predicted to be unstable.
Differences in age profiles of clinical malaria can be explained solely by P.
vivax's ability to relapse, which accelerates the acquisition of clinical immunity and serves as an immunity boosting mechanism.
P.
vivax transmission can subsist in areas of low mosquito abundance and is robust to drug administration initiatives due to relapse, making it an inconvenient and cumbersome, yet less lethal alternative to P.
falciparum.
American Psychological Association (APA)
Águas, Ricardo& Ferreira, Marcelo U.& Gomes, M. Gabriela M.. 2011. Modeling the Effects of Relapse in the Transmission Dynamics of Malaria Parasites. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-508339
Modern Language Association (MLA)
Águas, Ricardo…[et al.]. Modeling the Effects of Relapse in the Transmission Dynamics of Malaria Parasites. Journal of Parasitology Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-508339
American Medical Association (AMA)
Águas, Ricardo& Ferreira, Marcelo U.& Gomes, M. Gabriela M.. Modeling the Effects of Relapse in the Transmission Dynamics of Malaria Parasites. Journal of Parasitology Research. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-508339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508339