Evaluating the Ameliorative Potential of Quercetin against the Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats
Joint Authors
Patel, Manish
Gohel, Darpesh
Kushwah, Lokendra
Marvania, Tulsi
Balakrishnan, Suresh
Verma, Ramesh
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The current study deals with the effect of a dietary flavanoid quercetin on fibrotic lung tissue in rats.
Bleomycin was administered by single intratracheal instillation to Wistar rats to induce lung fibrosis.
The pathologies associated with this included significantly reduced antioxidant capacity, ultimately leading to protracted inflammation of the lung tissue.
The hallmark of this induced fibrosis condition was an excessive collagen deposition in peribronchial and perialveolar regions of the lung.
Oral quercetin treatment over a period of twenty days resulted in significant reversal of the pathologies.
The antioxidant defense in lung tissue was revived.
Moreover, activity of the collagenase MMP-7, which was high in fibrotic tissue, was seen restored after quercetin administration.
Trichome staining of lung tissue sections showed high collagen deposition in fibrotic rats, which may be a direct result of increased mobilization of collagen by MMP-7.
This was appreciably reduced in quercetin treated animals.
These results point towards an important protective role of quercetin against idiopathic lung fibrosis, which remains a widely prevalent yet incurable condition in the present times.
American Psychological Association (APA)
Verma, Ramesh& Kushwah, Lokendra& Gohel, Darpesh& Patel, Manish& Marvania, Tulsi& Balakrishnan, Suresh. 2013. Evaluating the Ameliorative Potential of Quercetin against the Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats. Pulmonary Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-508341
Modern Language Association (MLA)
Verma, Ramesh…[et al.]. Evaluating the Ameliorative Potential of Quercetin against the Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats. Pulmonary Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-508341
American Medical Association (AMA)
Verma, Ramesh& Kushwah, Lokendra& Gohel, Darpesh& Patel, Manish& Marvania, Tulsi& Balakrishnan, Suresh. Evaluating the Ameliorative Potential of Quercetin against the Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats. Pulmonary Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-508341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508341