Successful Use of Higher-Dose Etanercept for Multirefractory Systemic Flare of Adult-Onset Still’s Disease with Liver Failure with No Response to Tocilizumab Therapy
Joint Authors
Naniwa, Taio
Togawa, Hiroyuki
Maeda, Shinji
Tamechika, Shinya
Iwagaitsu, Shiho
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 21-year-old woman with refractory systemic flare of adult-onset Still’s disease with liver failure despite high-dose corticosteroids, cyclosporine, tacrolimus, and tocilizumab, was successfully treated with additional use of etanercept.
Etanercept at a dose of 50 mg weekly was partially effective but could not reduce the dose of concomitant betamethasone from 5 mg/day.
Etanercept at a dose of 75 mg weekly could lead her to clinical remission and enabled successful tapering off the corticosteroids and discontinuation of etanercept.
Normalization of serum C-reactive protein and interleukin 6 and persistent elevation of serum tumor necrosis factor α under the treatment with high-dose corticosteroids and immunosuppressants suggest that tumor necrosis factor α was more deeply involved than at least interleukin 6 in the pathogenesis of refractoriness of the disease in this patient, and these findings might be indicative of potential efficacy for adjunctive use of a tumor necrosis factor inhibitor rather than an interleukin 6 inhibitor.
American Psychological Association (APA)
Naniwa, Taio& Tamechika, Shinya& Iwagaitsu, Shiho& Maeda, Shinji& Togawa, Hiroyuki. 2013. Successful Use of Higher-Dose Etanercept for Multirefractory Systemic Flare of Adult-Onset Still’s Disease with Liver Failure with No Response to Tocilizumab Therapy. Case Reports in Rheumatology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-508411
Modern Language Association (MLA)
Naniwa, Taio…[et al.]. Successful Use of Higher-Dose Etanercept for Multirefractory Systemic Flare of Adult-Onset Still’s Disease with Liver Failure with No Response to Tocilizumab Therapy. Case Reports in Rheumatology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-508411
American Medical Association (AMA)
Naniwa, Taio& Tamechika, Shinya& Iwagaitsu, Shiho& Maeda, Shinji& Togawa, Hiroyuki. Successful Use of Higher-Dose Etanercept for Multirefractory Systemic Flare of Adult-Onset Still’s Disease with Liver Failure with No Response to Tocilizumab Therapy. Case Reports in Rheumatology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-508411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508411