Intravenous Thrombolytic Treatment in the Oldest Old
Joint Authors
Vivancos, José
Fuentes, Blanca
Egido, José Antonio
Martínez, Patricia
García-Caldentey, Juan
Alonso de Leciñana, María
Gil-Núñez, Antonio
García-Pastor, Andrés
Díez-Tejedor, Exuperio
Díaz-Otero, Fernando
Masjuan, Jaime
Reig, Gemma
García, Ana
Simal, Patricia
Guillán, Marta
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Purpose.
Intravenous thrombolysis using tissue plasminogen activator is safe and probably effective in patients >80 years old.
Nevertheless, its safety has not been specifically addressed for the oldest old patients (≥85 years old, OO).
We assessed the safety and effectiveness of thrombolysis in this group of age.
Methods.
A prospective registry of patients treated with intravenous thrombolysis.
Patients were divided in two groups (<85 years and the OO).
Demographic data, stroke aetiology and baseline National Institute Health Stroke Scale (NIHSS) score were recorded.
The primary outcome measures were the percentage of symptomatic intracranial haemorrhage (SICH) and functional outcome at 3 months (modified Rankin Scale, mRS).
Results.
A total of 1,505 patients were registered.
106 patients were OO [median 88, range 85–101].
Female sex, hypertension, elevated blood pressure at admission, cardioembolic strokes and higher basal NIHSS score were more frequent in the OO.
SICH transformation rates were similar (3.1% versus 3.7%, P=1.00).
The probability of independence at 3 months (mRS 0–2) was lower in the OO (40.2% versus 58.7%, P=0.001) but not after adjustment for confounding factors (adjusted OR, 0.82; 95% CI, 0.50 to 1.37; P=0.455).
Three-month mortality was higher in the OO (28.0% versus 11.5%, P<0.001).
Conclusion.
Intravenous thrombolysis for stroke in OO patients did not increase the risk of SICH although mortality was higher in this group.
American Psychological Association (APA)
García-Caldentey, Juan& Alonso de Leciñana, María& Simal, Patricia& Fuentes, Blanca& Reig, Gemma& Díaz-Otero, Fernando…[et al.]. 2012. Intravenous Thrombolytic Treatment in the Oldest Old. Stroke Research and Treatment،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-508422
Modern Language Association (MLA)
García-Caldentey, Juan…[et al.]. Intravenous Thrombolytic Treatment in the Oldest Old. Stroke Research and Treatment No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-508422
American Medical Association (AMA)
García-Caldentey, Juan& Alonso de Leciñana, María& Simal, Patricia& Fuentes, Blanca& Reig, Gemma& Díaz-Otero, Fernando…[et al.]. Intravenous Thrombolytic Treatment in the Oldest Old. Stroke Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-508422
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508422