Feasibility and Merits of Performing Preclinical Imaging on Clinical Radiology and Nuclear Medicine Systems
Author
Source
International Journal of Molecular Imaging
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
Researchers have limited access to systems dedicated to imaging small laboratory animals.
This paper aims to investigate the feasibility and merits of performing preclinical imaging on clinical systems.
Materials and Methods.
Scans were performed on rat and mouse models of diseases or injuries on four radiology systems, tomosynthesis, computed tomography (CT), positron emission tomography/computed tomography (PET-CT), and Magnetic Resonance Imaging (MRI), based on the availability at the author’s institute.
Results.
Tomosysthesis delineated soft tissue anatomy and hard tissue structure with superb contrast and spatial resolution at minimal scan time and effort.
CT allowed high resolution volumetric visualization of bones.
Molecular imaging with PET was useful for detecting cancerous tissue in mouse but at the expense of poor resolution.
MRI depicted abnormal or intervened tissue at quality and resolution sufficient for experimental studies.
The paper discussed limitations of the clinical systems in preclinical imaging as well as challenges regarding the need of additional gadgets, modifications, or upgrades required for longitudinally scanning animals under anesthesia while monitoring their vital signs.
Conclusion.
Clinical imaging technologies can potentially make cost-effective and efficient contributions to preclinical efforts in obtaining anatomical, structural, and functional information from the underlying tissue while minimally compromising the data quality in certain situations.
American Psychological Association (APA)
Bilgen, Mehmet. 2013. Feasibility and Merits of Performing Preclinical Imaging on Clinical Radiology and Nuclear Medicine Systems. International Journal of Molecular Imaging،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508440
Modern Language Association (MLA)
Bilgen, Mehmet. Feasibility and Merits of Performing Preclinical Imaging on Clinical Radiology and Nuclear Medicine Systems. International Journal of Molecular Imaging No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-508440
American Medical Association (AMA)
Bilgen, Mehmet. Feasibility and Merits of Performing Preclinical Imaging on Clinical Radiology and Nuclear Medicine Systems. International Journal of Molecular Imaging. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508440