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Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments
Joint Authors
Ahrné, Siv
Nyman, Margareta
Håkansson, Åsa
Molin, Göran
Bränning, Camilla
Hagslätt, Marie-Louise
Adawi, Diya
Jeppsson, Bengt
Source
Gastroenterology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model.
Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count of Enterobacteriaceae.
The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and lower proportions of butyrate in colonic content were found.
The DSS model seems to mimic the clinical situation and may be valuable for investigation of inflammation-related dysplasia and colon cancer, as well as for altered liver function by endogenous inflammatory mediators.
American Psychological Association (APA)
Håkansson, Åsa& Bränning, Camilla& Molin, Göran& Adawi, Diya& Hagslätt, Marie-Louise& Nyman, Margareta…[et al.]. 2011. Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments. Gastroenterology Research and Practice،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-508464
Modern Language Association (MLA)
Håkansson, Åsa…[et al.]. Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments. Gastroenterology Research and Practice No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-508464
American Medical Association (AMA)
Håkansson, Åsa& Bränning, Camilla& Molin, Göran& Adawi, Diya& Hagslätt, Marie-Louise& Nyman, Margareta…[et al.]. Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments. Gastroenterology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-508464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508464