Antibody-Based Therapies in Multiple Myeloma
Joint Authors
Anderson, Kenneth C.
Tai, Yu-Tzu
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The unmet need for improved multiple myeloma (MM) therapy has stimulated clinical development of monoclonal antibodies (mAbs) targeting either MM cells or cells of the bone marrow (BM) microenvironment.
In contrast to small-molecule inhibitors, therapeutic mAbs present the potential to specifically target tumor cells and directly induce an immune response to lyse tumor cells.
Unique immune-effector mechanisms are only triggered by therapeutic mAbs but not by small molecule targeting agents.
Although therapeutic murine mAbs or chimeric mAbs can cause immunogenicity, the advancement of genetic recombination for humanizing rodent mAbs has allowed large-scale production and designation of mAbs with better affinities, efficient selection, decreasing immunogenicity, and improved effector functions.
These advancements of antibody engineering technologies have largely overcome the critical obstacle of antibody immunogenicity and enabled the development and subsequent Food and Drug Administration (FDA) approval of therapeutic Abs for cancer and other diseases.
American Psychological Association (APA)
Tai, Yu-Tzu& Anderson, Kenneth C.. 2011. Antibody-Based Therapies in Multiple Myeloma. Bone Marrow Research،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-508465
Modern Language Association (MLA)
Tai, Yu-Tzu& Anderson, Kenneth C.. Antibody-Based Therapies in Multiple Myeloma. Bone Marrow Research No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-508465
American Medical Association (AMA)
Tai, Yu-Tzu& Anderson, Kenneth C.. Antibody-Based Therapies in Multiple Myeloma. Bone Marrow Research. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-508465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508465