A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease
Joint Authors
Nie, Yu
Zhao, Yan
Zheng, Zhe
Gu, Haiyong
Hu, Shengshou
Liu, Rui
Zhou, Zhou
Liu, Hanning
Teng, Xiao
Source
Biochemistry Research International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Coronary artery disease is the leading cause of mortality and morbidity in the world.
Left main coronary artery disease (LMCAD) is a particularly severe phenotypic form of CAD and has a genetic basis.
We hypothesized that some inflammation- and hyperhomocysteinemia-related gene polymorphisms may contribute to LMCAD susceptibility in a Chinese population.
We studied the association between polymorphisms in the genes hepatocyte nuclear factor 1 alpha (HNF1A; rs7310409, G/A), C-reactive protein (rs1800947 and rs3093059 T/C), methylenetetrahydrofolate reductase (rs1801133, C/T), and methylenetetrahydrofolate dehydrogenase (rs1076991, A/G) in 402 LMCAD and 804 more peripheral CAD patients in a Chinese population.
Genotyping was performed using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry method.
When the HNF1A rs7310409 GG homozygote genotype was used as the reference group, both the individual, GA and AA, and combined GA/AA genotypes were associated with an increased risk of LMCAD.
This single nucleotide polymorphism (rs7310409) is strongly associated with plasma CRP levels.
In conclusion, the present study provides evidence that the HNF1A rs7310409 G/A functional polymorphism may contribute to the risk of LMCAD.
American Psychological Association (APA)
Liu, Rui& Liu, Hanning& Gu, Haiyong& Teng, Xiao& Nie, Yu& Zhou, Zhou…[et al.]. 2014. A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease. Biochemistry Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-508469
Modern Language Association (MLA)
Liu, Rui…[et al.]. A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease. Biochemistry Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-508469
American Medical Association (AMA)
Liu, Rui& Liu, Hanning& Gu, Haiyong& Teng, Xiao& Nie, Yu& Zhou, Zhou…[et al.]. A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease. Biochemistry Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-508469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508469