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ETV6-RUNX1 Rearrangement in Tunisian Pediatric B-Lineage Acute Lymphoblastic Leukemia
Joint Authors
Elloumi, Moez
Khlif, Abderrahim
Elghezal, Hatem
Gmidène, Abir
Meddeb, Balkiss
Sennana, Hlima
Saad, Ali
Ben Youssef, Yosra
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
In this study, Forty-one out of fifty-seven Tunisian children with B-lineage acute lymphoblastic leukemia (B-ALL), and without cytogenetically detectable recurrent abnormalities at the time of the diagnosis, were evaluated by fluorescence in situ hybridization (FISH) for the t(12;21).
This translocation leads ETV6-RUNX1 (previously TEL-AML1) fusion gene.
16 patients (28%) had ETV6-RUNX1 rearrangement.
In addition to this rearrangement, two cases showed a loss of the normal ETV6 allele, and three others showed an extra signal of the RUNX1 gene.
Seven patients without ETV6-RUNX1 rearrangement showed extra signals of the RUNX1 gene.
One out of the 7 patients was also associated with a t(3;12) identified by FISH.
This is the first Tunisian study in which we report the incidence of t(12;21) among childhood B-lineage ALL and in which we have found multiple copies of RUNX1.
Finally, our findings confirm that additional or secondary genetic changes are commonly encountered in pediatric B-lineage ALL with ETV6-RUNX1 gene fusion which is envisaged to play a pivotal role in disease progression.
American Psychological Association (APA)
Gmidène, Abir& Elghezal, Hatem& Sennana, Hlima& Ben Youssef, Yosra& Meddeb, Balkiss& Elloumi, Moez…[et al.]. 2009. ETV6-RUNX1 Rearrangement in Tunisian Pediatric B-Lineage Acute Lymphoblastic Leukemia. Advances in Hematology،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-508489
Modern Language Association (MLA)
Gmidène, Abir…[et al.]. ETV6-RUNX1 Rearrangement in Tunisian Pediatric B-Lineage Acute Lymphoblastic Leukemia. Advances in Hematology No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-508489
American Medical Association (AMA)
Gmidène, Abir& Elghezal, Hatem& Sennana, Hlima& Ben Youssef, Yosra& Meddeb, Balkiss& Elloumi, Moez…[et al.]. ETV6-RUNX1 Rearrangement in Tunisian Pediatric B-Lineage Acute Lymphoblastic Leukemia. Advances in Hematology. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-508489
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508489