Mercury Toxicity on Sodium Pump and Organoseleniums Intervention : A Paradox
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Mercury is an environmental poison, and the damage to living system is generally severe.
The severity of mercury poisoning is consequent from the fact that it targets the thiol-containing enzymes, irreversibly oxidizing their critical thiol groups, consequently leading to an inactivation of the enzyme.
The Na+/K+-ATPase is a sulfhydryl protein that is sensitive to Hg2+ assault.
On the other hand, organoseleniums are a class of pharmacologically promising compounds with potent antioxidant effects.
While Hg2+ oxidizes sulfhydryl groups of Na+/K+-ATPase under in vitro and in vivo conditions, the organoselenium compounds inhibit Na+/K+-ATPase in vitro but enhance its activities under in vivo conditions with concomitant increase in the level of endogenous thiols.
Paradoxically, it appears that these two thiol oxidants can be used to counteract one another under in vivo conditions, and this hypothesis serves as the basis for this paper.
American Psychological Association (APA)
Kade, Ige Joseph. 2012. Mercury Toxicity on Sodium Pump and Organoseleniums Intervention : A Paradox. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-508502
Modern Language Association (MLA)
Kade, Ige Joseph. Mercury Toxicity on Sodium Pump and Organoseleniums Intervention : A Paradox. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-508502
American Medical Association (AMA)
Kade, Ige Joseph. Mercury Toxicity on Sodium Pump and Organoseleniums Intervention : A Paradox. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-508502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508502