Multiple Effects of Berberine Derivatives on Colon Cancer Cells
Joint Authors
Prosperi, Ennio
Parks, Michael
Buzzetti, Franco
Arcamone, Andrea G.
Guamán Ortiz, Luis Miguel
Scovassi, Anna Ivana
Dutto, Ilaria
Lombardi, Paolo
Tillhon, Micol
Savio, Monica
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The pharmacological use of the plant alkaloid berberine is based on its antibacterial and anti-inflammatory properties; recently, anticancer activity has been attributed to this compound.
To exploit this interesting feature, we synthesized three berberine derivatives, namely, NAX012, NAX014, and NAX018, and we tested their effects on two human colon carcinoma cell lines, that is, HCT116 and SW613-B3, which are characterized by wt and mutated p53, respectively.
We observed that cell proliferation is more affected by cell treatment with the derivatives than with the lead compound; moreover, the derivatives proved to induce cell cycle arrest and cell death through apoptosis, thus suggesting that they could be promising anticancer drugs.
Finally, we detected typical signs of autophagy in cells treated with berberine derivatives.
American Psychological Association (APA)
Guamán Ortiz, Luis Miguel& Tillhon, Micol& Parks, Michael& Dutto, Ilaria& Prosperi, Ennio& Savio, Monica…[et al.]. 2014. Multiple Effects of Berberine Derivatives on Colon Cancer Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-508508
Modern Language Association (MLA)
Guamán Ortiz, Luis Miguel…[et al.]. Multiple Effects of Berberine Derivatives on Colon Cancer Cells. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-508508
American Medical Association (AMA)
Guamán Ortiz, Luis Miguel& Tillhon, Micol& Parks, Michael& Dutto, Ilaria& Prosperi, Ennio& Savio, Monica…[et al.]. Multiple Effects of Berberine Derivatives on Colon Cancer Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-508508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508508