Amyotrophic Lateral Sclerosis : A Focus on Disease Progression
Joint Authors
Calvo, Ana Cristina
Osta, Rosario
Zaragoza, Pilar
Manzano, Raquel
Muñoz, María J.
Mendonça, Deise M. F.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Since amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a neurodegenerative disease in which motor neuron death is induced, a wide range of biomarkers have been selected to identify therapeutic targets.
ALS shares altered molecular pathways with other neurodegenerative diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s diseases.
However, the molecular targets that directly influence its aggressive nature remain unknown.
What is the first link in the neurodegenerative chain of ALS that makes this disease so peculiar? In this review, we will discuss the progression of the disease from the viewpoint of the potential biomarkers described to date in human and animal model samples.
Finally, we will consider potential therapeutic strategies for ALS treatment and future, innovative perspectives.
American Psychological Association (APA)
Calvo, Ana Cristina& Manzano, Raquel& Mendonça, Deise M. F.& Muñoz, María J.& Zaragoza, Pilar& Osta, Rosario. 2014. Amyotrophic Lateral Sclerosis : A Focus on Disease Progression. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-508559
Modern Language Association (MLA)
Calvo, Ana Cristina…[et al.]. Amyotrophic Lateral Sclerosis : A Focus on Disease Progression. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-508559
American Medical Association (AMA)
Calvo, Ana Cristina& Manzano, Raquel& Mendonça, Deise M. F.& Muñoz, María J.& Zaragoza, Pilar& Osta, Rosario. Amyotrophic Lateral Sclerosis : A Focus on Disease Progression. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-508559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508559