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Telomere Length Reprogramming in Embryos and Stem Cells
Joint Authors
Robinson, LeRoy G.
Liu, Lin
Wang, Fang
Kalmbach, Keri
Keefe, David
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Telomeres protect and cap linear chromosome ends, yet these genomic buffers erode over an organism’s lifespan.
Short telomeres have been associated with many age-related conditions in humans, and genetic mutations resulting in short telomeres in humans manifest as syndromes of precocious aging.
In women, telomere length limits a fertilized egg’s capacity to develop into a healthy embryo.
Thus, telomere length must be reset with each subsequent generation.
Although telomerase is purportedly responsible for restoring telomere DNA, recent studies have elucidated the role of alternative telomeres lengthening mechanisms in the reprogramming of early embryos and stem cells, which we review here.
American Psychological Association (APA)
Kalmbach, Keri& Robinson, LeRoy G.& Wang, Fang& Liu, Lin& Keefe, David. 2014. Telomere Length Reprogramming in Embryos and Stem Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-508562
Modern Language Association (MLA)
Kalmbach, Keri…[et al.]. Telomere Length Reprogramming in Embryos and Stem Cells. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-508562
American Medical Association (AMA)
Kalmbach, Keri& Robinson, LeRoy G.& Wang, Fang& Liu, Lin& Keefe, David. Telomere Length Reprogramming in Embryos and Stem Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-508562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508562