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CD4+T Cells : Differentiation and Functions
Joint Authors
Xia, Bing
Verma, Asha Devi
Luckheeram, Rishi Vishal
Zhou, Rui
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
CD4+T cells are crucial in achieving a regulated effective immune response to pathogens.
Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment.
Besides the classical T-helper 1 and T-helper 2, other subsets have been identified, including T-helper 17, regulatory T cell, follicular helper T cell, and T-helper 9, each with a characteristic cytokine profile.
For a particular phenotype to be differentiated, a set of cytokine signaling pathways coupled with activation of lineage-specific transcription factors and epigenetic modifications at appropriate genes are required.
The effector functions of these cells are mediated by the cytokines secreted by the differentiated cells.
This paper will focus on the cytokine-signaling and the network of transcription factors responsible for the differentiation of naive CD4+T cells.
American Psychological Association (APA)
Luckheeram, Rishi Vishal& Zhou, Rui& Verma, Asha Devi& Xia, Bing. 2012. CD4+T Cells : Differentiation and Functions. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-508564
Modern Language Association (MLA)
Luckheeram, Rishi Vishal…[et al.]. CD4+T Cells : Differentiation and Functions. Clinical and Developmental Immunology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-508564
American Medical Association (AMA)
Luckheeram, Rishi Vishal& Zhou, Rui& Verma, Asha Devi& Xia, Bing. CD4+T Cells : Differentiation and Functions. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-508564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508564