Chemical Methods to Induce Beta-Cell Proliferation
Joint Authors
Wagner, Bridget K.
Vetere, Amedeo
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pancreatic beta-cell regeneration, for example, by inducing proliferation, remains an important goal in developing effective treatments for diabetes.
However, beta cells have mainly been considered quiescent.
This “static” view has recently been challenged by observations of relevant physiological conditions in which metabolic stress is compensated by an increase in beta-cell mass.
Understanding the molecular mechanisms underlining these process could open the possibility of developing novel small molecules to increase beta-cell mass.
Several cellular cell-cycle and signaling proteins provide attractive targets for high throughput screening, and recent advances in cell culture have enabled phenotypic screening for small molecule-induced beta-cell proliferation.
We present here an overview of the current trends involving small-molecule approaches to induce beta-cell regeneration by proliferation.
American Psychological Association (APA)
Vetere, Amedeo& Wagner, Bridget K.. 2012. Chemical Methods to Induce Beta-Cell Proliferation. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-508567
Modern Language Association (MLA)
Vetere, Amedeo& Wagner, Bridget K.. Chemical Methods to Induce Beta-Cell Proliferation. International Journal of Endocrinology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-508567
American Medical Association (AMA)
Vetere, Amedeo& Wagner, Bridget K.. Chemical Methods to Induce Beta-Cell Proliferation. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-508567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508567