TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis
Joint Authors
Muzi, Paola
Lauriello, Maria
Micera, Alessandra
Di Rienzo Businco, Lino
Bonini, Sergio
Source
International Journal of Otolaryngology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Toll-like receptors (TLRs) represent a family of evolutionarily conserved proteins, that represent a fundamental link between innate and adaptive immune responses.
Aim.
The purpose of this study was to investigate the expression of TLR4 and TLR9 in the normal nasal mucosa and in the mucosa of subjects with different phenotypes of rhinitis.
Methodology.
A confocal analysis of TLR4 and TLR9 (co)expression was carried out on biopsies from the inferior turbinate obtained from 4 patients affected by persistent allergic rhinitis, 8 patients with chronic rhino-sinusitis, and 6 patients with vasomotor rhinitis The results were compared with those of specimens obtained from 4 subjects undergoing nasal surgery, but with signs of nasal inflammation.
Results.
TLR4 and TLR9 were expressed in the healthy nasal mucosa; TLR4 and TLR9 expression was significantly decreased in allergic rhinitis.
TLR4 was over expressed in the epithelium of chronic rhino-sinusitis.
Both TLRs were co-expressed in the sub-epithelial infiltrate of chronic and vasomotor rhinitis, even though this expression was higher in the former compared with the latter.
Conclusions.
This study indicates that TLR4 and TLR9 show a different pattern of expression in different phenotypes of rhinitis, possibly related to the type and severity of the disease.
American Psychological Association (APA)
Lauriello, Maria& Micera, Alessandra& Muzi, Paola& Di Rienzo Businco, Lino& Bonini, Sergio. 2012. TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis. International Journal of Otolaryngology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-508569
Modern Language Association (MLA)
Lauriello, Maria…[et al.]. TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis. International Journal of Otolaryngology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-508569
American Medical Association (AMA)
Lauriello, Maria& Micera, Alessandra& Muzi, Paola& Di Rienzo Businco, Lino& Bonini, Sergio. TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis. International Journal of Otolaryngology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-508569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508569