![](/images/graphics-bg.png)
Activation of TRPV1 Prevents OxLDL-Induced Lipid Accumulation and TNF-α-Induced Inflammation in Macrophages : Role of Liver X Receptor α
Joint Authors
Ching, Li-Chieh
Zhao, Jin-Feng
Wei, Jeng
Shyue, Song-Kun
Kou, Yu Ru
Lin, Shing-Jong
Lee, Tzong-Shyuan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The transient receptor potential vanilloid type 1 (TRPV1) is crucial in the pathogenesis of atherosclerosis; yet its role and underlying mechanism in the formation of macrophage foam cells remain unclear.
Here, we show increased TRPV1 expression in the area of foamy macrophages in atherosclerotic aortas of apolipoprotein E-deficient mice.
Exposure of mouse bone-marrow-derived macrophages to oxidized low-density lipoprotein (oxLDL) upregulated the expression of TRPV1.
In addition, oxLDL activated TRPV1 and elicited calcium (Ca2+) influx, which were abrogated by the pharmacological TRPV1 antagonist capsazepine.
Furthermore, oxLDL-induced lipid accumulation in macrophages was ameliorated by TRPV1 agonists but exacerbated by TRPV1 antagonist.
Treatment with TRPV1 agonists did not affect the internalization of oxLDL but promoted cholesterol efflux by upregulating the efflux ATP-binding cassette (ABC) transporters ABCA1 and ABCG1.
Moreover, the upregulation of ABC transporters was mainly through liver X receptor α- (LXRα-) dependent regulation of transcription.
Moreover, the TNF-α-induced inflammatory response was alleviated by TRPV1 agonists but aggravated by the TRPV1 antagonist and LXRα siRNA in macrophages.
Our data suggest that LXRα plays a pivotal role in TRPV1-activation-conferred protection against oxLDL-induced lipid accumulation and TNF-α-induced inflammation in macrophages.
American Psychological Association (APA)
Zhao, Jin-Feng& Ching, Li-Chieh& Kou, Yu Ru& Lin, Shing-Jong& Wei, Jeng& Shyue, Song-Kun…[et al.]. 2013. Activation of TRPV1 Prevents OxLDL-Induced Lipid Accumulation and TNF-α-Induced Inflammation in Macrophages : Role of Liver X Receptor α. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-508571
Modern Language Association (MLA)
Zhao, Jin-Feng…[et al.]. Activation of TRPV1 Prevents OxLDL-Induced Lipid Accumulation and TNF-α-Induced Inflammation in Macrophages : Role of Liver X Receptor α. Mediators of Inflammation No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-508571
American Medical Association (AMA)
Zhao, Jin-Feng& Ching, Li-Chieh& Kou, Yu Ru& Lin, Shing-Jong& Wei, Jeng& Shyue, Song-Kun…[et al.]. Activation of TRPV1 Prevents OxLDL-Induced Lipid Accumulation and TNF-α-Induced Inflammation in Macrophages : Role of Liver X Receptor α. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-508571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508571