Vascular Adhesion Protein 1 in the Eye
Joint Authors
Luo, Wenting
Zhang, Zhongyu
Xie, Fang
Sun, Dawei
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1), a dual-function molecule with adhesive and enzymatic properties, is expressed on the surface of vascular endothelial cells of mammals.
It also exists as a soluble form (sVAP-1), which is implicated in oxidative stress via its enzymatic activity and can be a prognostic biomarker.
Recent evidence suggests that VAP-1 is an important therapeutic target for several inflammation-related ocular diseases, such as uveitis, age-related macular degeneration (AMD), and diabetic retinopathy (DR), by involving in the recruitment of leukocytes at sites of inflammation.
Furthermore, VAP-1 plays an important role in the pathogenesis of conjunctival inflammatory diseases such as pyogenic granulomas and the progression of conjunctival lymphoma.
VAP-1 may be an alternative therapeutic target in ocular diseases.
The in vivo imaging of inflammation using VAP-1 as a target molecule is a novel approach with a potential for early detection and characterization of inflammatory diseases.
This paper reviews the critical roles of VAP-1 in ophthalmological diseases which may provide a novel research direction or a potent therapeutic strategy.
American Psychological Association (APA)
Luo, Wenting& Xie, Fang& Zhang, Zhongyu& Sun, Dawei. 2013. Vascular Adhesion Protein 1 in the Eye. Journal of Ophthalmology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508576
Modern Language Association (MLA)
Luo, Wenting…[et al.]. Vascular Adhesion Protein 1 in the Eye. Journal of Ophthalmology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-508576
American Medical Association (AMA)
Luo, Wenting& Xie, Fang& Zhang, Zhongyu& Sun, Dawei. Vascular Adhesion Protein 1 in the Eye. Journal of Ophthalmology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508576