Cross-Talk between PPARs and the Partners of RXR : A Molecular Perspective
Joint Authors
Wells, Richard A.
Chan, Lap Shu Alan
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The PPARs are integral parts of the RXR-dependent signaling networks.
Many other nuclear receptor subfamily 1 members also require RXR as their obligatory heterodimerization partner and they are often co-expressed in any given tissue.
Therefore, the PPARs often complete with other RXR-dependent nuclear receptors and this competition has important biological implications.
Thorough understanding of this cross-talk at the molecular level is crucial to determine the detailed functional roles of the PPARs.
At the level of DNA binding, most RXR heterodimers bind selectively to the well-known “DR1 to 5” DNA response elements.
As a result, many heterodimers share the same DR element and must complete with each other for DNA binding.
At the level of heterodimerization, the partners of RXR share the same RXR dimerization interface.
As a result, individual nuclear receptors must complete with each other for RXR to form functional heterodimers.
Cross-talk through DNA binding and RXR heterodimerization present challenges to the study of these nuclear receptors that cannot be adequately addressed by current experimental approaches.
Novel tools, such as engineered nuclear receptors with altered dimerization properties, are currently being developed.
These tools will enable future studies to dissect specific RXR heterodimers and their signaling pathways.
American Psychological Association (APA)
Chan, Lap Shu Alan& Wells, Richard A.. 2009. Cross-Talk between PPARs and the Partners of RXR : A Molecular Perspective. PPAR Research،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-508583
Modern Language Association (MLA)
Chan, Lap Shu Alan& Wells, Richard A.. Cross-Talk between PPARs and the Partners of RXR : A Molecular Perspective. PPAR Research No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-508583
American Medical Association (AMA)
Chan, Lap Shu Alan& Wells, Richard A.. Cross-Talk between PPARs and the Partners of RXR : A Molecular Perspective. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-508583
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508583