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FOXO Transcription Factors : Their Clinical Significance and Regulation
Joint Authors
Zhou, Yanmin
Wang, Yu
Graves, Dana T.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Members of the class O of forkhead box transcription factors (FOXO) have important roles in metabolism, cellular proliferation, stress resistance, and apoptosis.
The activity of FOXOs is tightly regulated by posttranslational modification, including phosphorylation, acetylation, and ubiquitylation.
Activation of cell survival pathways such as phosphoinositide-3-kinase/AKT/IKK or RAS/mitogen-activated protein kinase phosphorylates FOXOs at different sites which regulate FOXOs nuclear localization or degradation.
FOXO transcription factors are upregulated in a number of cell types including hepatocytes, fibroblasts, osteoblasts, keratinocytes, endothelial cells, pericytes, and cardiac myocytes.
They are involved in a number of pathologic and physiologic processes that include proliferation, apoptosis, autophagy, metabolism, inflammation, cytokine expression, immunity, differentiation, and resistance to oxidative stress.
These processes impact a number of clinical conditions such as carcinogenesis, diabetes, diabetic complications, cardiovascular disease, host response, and wound healing.
In this paper, we focus on the potential role of FOXOs in different disease models and the regulation of FOXOs by various stimuli.
American Psychological Association (APA)
Wang, Yu& Zhou, Yanmin& Graves, Dana T.. 2014. FOXO Transcription Factors : Their Clinical Significance and Regulation. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-508588
Modern Language Association (MLA)
Wang, Yu…[et al.]. FOXO Transcription Factors : Their Clinical Significance and Regulation. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-508588
American Medical Association (AMA)
Wang, Yu& Zhou, Yanmin& Graves, Dana T.. FOXO Transcription Factors : Their Clinical Significance and Regulation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-508588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508588