Prevention and Restoration of Hearing Loss Associated with the Use of Cisplatin
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Cisplatin is a well known platinum-based chemotherapeutic agent used for the treatment of various malignant tumours.
A frequent side effect of cisplatin therapy is ototoxicity.
Unfortunately, currently there are no available treatments.
Material and Methods.
Experimental, clinical studies and reviews published between 2004 and 2014 in the English medical literature concerning ototoxicity were selected using Medline, PubMed, and Google Scholar databases.
Inclusion criteria were cisplatin-induced ototoxicity and therapy aimed at preventing or curing this disorder.
Molecular mechanisms and clinical, audiological, and histological markers of cisplatin-induced ototoxicity are described.
Moreover, experimental and clinical strategies for prevention or treatment of hearing loss were also reviewed.
Results and Discussion.
Experimental studies demonstrate a wide range of otoprotective molecules and strategies efficient against cisplatin-induced hearing loss.
However, only dexamethasone proved a slight otoprotective effect in a clinical study.
Conclusion.
Further research must be completed to bring future therapeutic options into clinical setting.
American Psychological Association (APA)
Chirtes, Felician& Albu, Silviu. 2014. Prevention and Restoration of Hearing Loss Associated with the Use of Cisplatin. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-508599
Modern Language Association (MLA)
Chirtes, Felician& Albu, Silviu. Prevention and Restoration of Hearing Loss Associated with the Use of Cisplatin. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-508599
American Medical Association (AMA)
Chirtes, Felician& Albu, Silviu. Prevention and Restoration of Hearing Loss Associated with the Use of Cisplatin. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-508599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508599