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Phytoagents for Cancer Management : Regulation of Nucleic Acid Oxidation, ROS, and Related Mechanisms
Joint Authors
Shyur, Lie-Fen
Lee, Wai-Leng
Huang, Jing-Ying
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-25
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Accumulation of oxidized nucleic acids causes genomic instability leading to senescence, apoptosis, and tumorigenesis.
Phytoagents are known to reduce the risk of cancer development; whether such effects are through regulating the extent of nucleic acid oxidation remains unclear.
Here, we outlined the role of reactive oxygen species in nucleic acid oxidation as a driving force in cancer progression.
The consequential relationship between genome instability and cancer progression highlights the importance of modulation of cellular redox level in cancer management.
Current epidemiological and experimental evidence demonstrate the effects and modes of action of phytoagents in nucleic acid oxidation and provide rationales for the use of phytoagents as chemopreventive or therapeutic agents.
Vitamins and various phytoagents antagonize carcinogen-triggered oxidative stress by scavenging free radicals and/or activating endogenous defence systems such as Nrf2-regulated antioxidant genes or pathways.
Moreover, metal ion chelation by phytoagents helps to attenuate oxidative DNA damage caused by transition metal ions.
Besides, the prooxidant effects of some phytoagents pose selective cytotoxicity on cancer cells and shed light on a new strategy of cancer therapy.
The “double-edged sword” role of phytoagents as redox regulators in nucleic acid oxidation and their possible roles in cancer prevention or therapy are discussed in this review.
American Psychological Association (APA)
Lee, Wai-Leng& Huang, Jing-Ying& Shyur, Lie-Fen. 2013. Phytoagents for Cancer Management : Regulation of Nucleic Acid Oxidation, ROS, and Related Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-22.
https://search.emarefa.net/detail/BIM-508620
Modern Language Association (MLA)
Lee, Wai-Leng…[et al.]. Phytoagents for Cancer Management : Regulation of Nucleic Acid Oxidation, ROS, and Related Mechanisms. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-22.
https://search.emarefa.net/detail/BIM-508620
American Medical Association (AMA)
Lee, Wai-Leng& Huang, Jing-Ying& Shyur, Lie-Fen. Phytoagents for Cancer Management : Regulation of Nucleic Acid Oxidation, ROS, and Related Mechanisms. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-22.
https://search.emarefa.net/detail/BIM-508620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508620