Molecular Mechanism Underlying Lymphatic Metastasis in Pancreatic Cancer
Joint Authors
Yu, Xianjun
Liu, Liang
Ni, Quanxing
Liu, Zuqiang
Luo, Guopei
Xiao, Zhiwen
Wu, Chuntao
Long, Jiang
Liu, Chen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-22
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
As the most challenging human malignancies, pancreatic cancer is characterized by its insidious symptoms, low rate of surgical resection, high risk of local invasion, metastasis and recurrence, and overall dismal prognosis.
Lymphatic metastasis, above all, is recognized as an early adverse event in progression of pancreatic cancer and has been described to be an independent poor prognostic factor.
It should be noted that the occurrence of lymphatic metastasis is not a casual or stochastic but an ineluctable and designed event.
Increasing evidences suggest that metastasis-initiating cells (MICs) and the microenvironments may act as a double-reed style in this crime.
However, the exact mechanisms on how they function synergistically for this dismal clinical course remain largely elusive.
Therefore, a better understanding of its molecular and cellular mechanisms involved in pancreatic lymphatic metastasis is urgently required.
In this review, we will summarize the latest advances on lymphatic metastasis in pancreatic cancer.
American Psychological Association (APA)
Xiao, Zhiwen& Luo, Guopei& Liu, Chen& Wu, Chuntao& Liu, Liang& Liu, Zuqiang…[et al.]. 2014. Molecular Mechanism Underlying Lymphatic Metastasis in Pancreatic Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-508624
Modern Language Association (MLA)
Xiao, Zhiwen…[et al.]. Molecular Mechanism Underlying Lymphatic Metastasis in Pancreatic Cancer. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-508624
American Medical Association (AMA)
Xiao, Zhiwen& Luo, Guopei& Liu, Chen& Wu, Chuntao& Liu, Liang& Liu, Zuqiang…[et al.]. Molecular Mechanism Underlying Lymphatic Metastasis in Pancreatic Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-508624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508624