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Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives
Joint Authors
Silva, Moara Targino da
Lima, Vera Lúcia de Menezes
Assis, Shalom Pôrto de Oliveira
de Oliveira, Ronaldo Nascimento
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Four new 1,2,3-triazole phthalimide derivatives with a potent anti-inflammatory activity have been synthesized in the good yields by the 1,3-dipolar cycloaddition reaction from N-(azido-alkyl)phthalimides and terminal alkynes.
The anti-inflammatory activity was determined by injecting carrageenan through the plantar tissue of the right hind paw of Swiss white mice to produce inflammation.
All the compounds 3a–c and 5a–c exhibited an important anti-inflammatory activity; the best activity was found for the compounds 3b and 5c, which showed to be able to decrease by 69% and 56.2% carrageenan-induced edema in mice.
These compounds may also offer a future promise as a new anti-inflammatory agent.
American Psychological Association (APA)
Assis, Shalom Pôrto de Oliveira& Silva, Moara Targino da& de Oliveira, Ronaldo Nascimento& Lima, Vera Lúcia de Menezes. 2012. Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-508631
Modern Language Association (MLA)
Assis, Shalom Pôrto de Oliveira…[et al.]. Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives. The Scientific World Journal No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-508631
American Medical Association (AMA)
Assis, Shalom Pôrto de Oliveira& Silva, Moara Targino da& de Oliveira, Ronaldo Nascimento& Lima, Vera Lúcia de Menezes. Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-508631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508631