FC-98 Regulates TLR9-Mediated of CXCL-10 Expression in Dendritic Cells via MAPK and STAT1 Signaling Pathway
Joint Authors
Gong, Wei
Yang, Yonghong
Li, Xiaoqin
Dou, Huan
Hou, Yayi
Tan, Ren Xiang
Song, Yuxian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dendritic cells (DCs), as the most potent professional antigen presenting cells, play a crucial role in both innate and adaptive immune systems.
Genomic bacterial DNA mimicked by unmethylated CpG motifs is discovered to possess immunostimulatory effects.
CpG-DNA recognized by Toll-like receptor 9 (TLR9) on DCs arouses many immune diseases (such as cancer, viral infection, and autoimmune disorders).
In this study we investigated the effects of FC-98 on CpG-induced bone marrow-derived DCs (BMDCs).
The results showed that FC-98 significantly inhibited the CpG-induced BMDCs maturation and function by suppressing the expression of surface markers (CD40, CD80, CD86, and MHCII).
Moreover, FC-98 downregulated the expression of C-X-C motif chemokine 10 (CXCL-10) both at the mRNA and protein level after CpG induction.
Meanwhile, FC-98 markedly affected the migration of BMDCs to T cells without affecting their endocytosis capacity.
Furthermore, FC-98 was confirmed to decrease CXCL-10 expression by inhibiting CpG-induced activation of MAPKs (ERK, JNK, and p38) and STAT1 signaling.
Overall, these results suggested that FC-98 was a potential molecule in the treatment of CXCL-10-mediated immune diseases.
American Psychological Association (APA)
Yang, Yonghong& Dou, Huan& Li, Xiaoqin& Song, Yuxian& Gong, Wei& Tan, Ren Xiang…[et al.]. 2014. FC-98 Regulates TLR9-Mediated of CXCL-10 Expression in Dendritic Cells via MAPK and STAT1 Signaling Pathway. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-508650
Modern Language Association (MLA)
Yang, Yonghong…[et al.]. FC-98 Regulates TLR9-Mediated of CXCL-10 Expression in Dendritic Cells via MAPK and STAT1 Signaling Pathway. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-508650
American Medical Association (AMA)
Yang, Yonghong& Dou, Huan& Li, Xiaoqin& Song, Yuxian& Gong, Wei& Tan, Ren Xiang…[et al.]. FC-98 Regulates TLR9-Mediated of CXCL-10 Expression in Dendritic Cells via MAPK and STAT1 Signaling Pathway. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-508650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508650