LH Pretreatment as a Novel Strategy for Poor Responders
Joint Authors
Ferraretti, Anna Pia
Gianaroli, Luca
Motrenko, Tatiana
Magli, Maria Cristina
Tabanelli, Carla
Feliciani, Elisabetta
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Poor response to ovarian stimulation is still a major problem in IVF.
The study presents a new stimulation protocol evaluated in a suppopulation of very difficult young poor ovarian responders.
Material and Methods.
The study consists in two sections.
The first includes data from a randomized controlled study involving forty-three young patients with a poor ovarian response in at least two previous cycles (intended as cycle cancellation or with ≤3 collected oocytes).
Patients were randomized in two groups: group A (control) received FSH (400 IU/day), while group B received the new stimulation protocol consisting in a sequential association of 150 IU r-LH for 4 days followed by 400 IU r-FSH/after downregulation with daily GnRh agonist.
The second includes data from the overall results in 65 patients treated with the new protocol compared to their previous performance with conventional cycles (historical control).
Results.
Both in the RCT and in the historical control study, LH pretreatment was able to decrease the cancellation rate, to improve the in vitro performance, and to significantly increase the live birth rates.
Conclusions.
LH pretreatment improved oocyte quantity and quality in young repeated poor responders selected in accordance with the Bologna criteria.
American Psychological Association (APA)
Ferraretti, Anna Pia& Gianaroli, Luca& Motrenko, Tatiana& Feliciani, Elisabetta& Tabanelli, Carla& Magli, Maria Cristina. 2014. LH Pretreatment as a Novel Strategy for Poor Responders. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-508655
Modern Language Association (MLA)
Ferraretti, Anna Pia…[et al.]. LH Pretreatment as a Novel Strategy for Poor Responders. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-508655
American Medical Association (AMA)
Ferraretti, Anna Pia& Gianaroli, Luca& Motrenko, Tatiana& Feliciani, Elisabetta& Tabanelli, Carla& Magli, Maria Cristina. LH Pretreatment as a Novel Strategy for Poor Responders. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-508655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508655