Bimatoprost Effects on Aqueous Humor Dynamics in Monkeys
Joint Authors
Woodward, David F.
Krauss, Achim H.-P.
Nilsson, Siv F. E.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The effects of bimatoprost on aqueous humor dynamics were quantified in monkey eyes.
Uveoscleral outflow was measured by the anterior chamber perfusion method, using FITC-dextran.
Total outflow facility was determined by the two-level constant pressure method.
Aqueous flow was measured with a scanning ocular fluorophotometer.
Uveoscleral outflow was 0.96±0.19 μL min−1 in vehicle-treated eyes and 1.37±0.27 μL min−1 (n=6; P<.05) in eyes that received bimatoprost 0.01% b.i.d.
× 5 days.
Bimatoprost had no effect on total outflow facility, which was 0.42±0.05 μL min−1 at baseline and 0.42±0.04 μL min−1 after bimatoprost treatment.
Bimatoprost had no significant effect on aqueous humor flow.
This study demonstrates that bimatoprost increases uveoscleral outflow but not total outflow facility or aqueous humor flow, indicating that it lowers intraocular pressure in ocular normotensive monkeys by a mechanism that exclusively involves uveoscleral outflow.
American Psychological Association (APA)
Woodward, David F.& Krauss, Achim H.-P.& Nilsson, Siv F. E.. 2010. Bimatoprost Effects on Aqueous Humor Dynamics in Monkeys. Journal of Ophthalmology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-508658
Modern Language Association (MLA)
Woodward, David F.…[et al.]. Bimatoprost Effects on Aqueous Humor Dynamics in Monkeys. Journal of Ophthalmology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-508658
American Medical Association (AMA)
Woodward, David F.& Krauss, Achim H.-P.& Nilsson, Siv F. E.. Bimatoprost Effects on Aqueous Humor Dynamics in Monkeys. Journal of Ophthalmology. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-508658
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508658