Transition Metal(II) Complexes with Cefotaxime-Derived Schiff Base : Synthesis, Characterization, and Antimicrobial Studies
Joint Authors
Amzoiu, Emilia
Reiss, Aurora
Spînu, Cezar Ionuţ
Chifiriuc, Mariana Carmen
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-12
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
New [ML2(H2O)2] complexes, where M = Co(II), Ni(II), Cu(II), and Zn(II) while L corresponds to the Schiff base ligand, were synthesized by condensation of cefotaxime with salicylaldehyde in situ in the presence of divalent metal salts in ethanolic medium.
The complexes were characterized by elemental analyses, conductance, and magnetic measurements, as well as by IR and UV-Vis spectroscopy.
The low values of the molar conductance indicate nonelectrolyte type of complexes.
Based on spectral data and magnetic moments, an octahedral geometry may be proposed for Co(II), Ni(II), and Zn(II) complexes while a tetragonal geometry for Cu(II) complex.
Molecular structure of the Schiff base ligand and its complexes were studied using programs dedicated to chemical modeling and quantomolecular calculation of chemical properties.
All the synthesized complexes were tested for in vitro antibacterial activity against some pathogenic bacterial strains, namely Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus.
The MIC values shown by the complexes against these bacterial strains revealed that the metal complexes possess superior antibacterial activity than the Schiff base.
American Psychological Association (APA)
Reiss, Aurora& Chifiriuc, Mariana Carmen& Amzoiu, Emilia& Spînu, Cezar Ionuţ. 2014. Transition Metal(II) Complexes with Cefotaxime-Derived Schiff Base : Synthesis, Characterization, and Antimicrobial Studies. Bioinorganic Chemistry and Applications،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-508666
Modern Language Association (MLA)
Reiss, Aurora…[et al.]. Transition Metal(II) Complexes with Cefotaxime-Derived Schiff Base : Synthesis, Characterization, and Antimicrobial Studies. Bioinorganic Chemistry and Applications No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-508666
American Medical Association (AMA)
Reiss, Aurora& Chifiriuc, Mariana Carmen& Amzoiu, Emilia& Spînu, Cezar Ionuţ. Transition Metal(II) Complexes with Cefotaxime-Derived Schiff Base : Synthesis, Characterization, and Antimicrobial Studies. Bioinorganic Chemistry and Applications. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-508666
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508666