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Targeting Costimulatory Molecules to Improve Antitumor Immunity
Joint Authors
Fischietti, Mariafausta
Verzella, Daniela
Capece, Daria
Alesse, Edoardo
Zazzeroni, Francesca
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The full activation of T cells necessitates the concomitant activation of two signals, the engagement of T-cell receptor by peptide/major histocompatibility complex II and an additional signal delivered by costimulatory molecules.
The best characterized costimulatory molecules belong to B7/CD28 and TNF/TNFR families and play crucial roles in the modulation of immune response and improvement of antitumor immunity.
Unfortunately, tumors often generate an immunosuppressive microenvironment, where T-cell response is attenuated by the lack of costimulatory molecules on the surface of cancer cells.
Thus, targeting costimulatory pathways represent an attractive therapeutic strategy to enhance the antitumor immunity in several human cancers.
Here, latest therapeutic approaches targeting costimulatory molecules will be described.
American Psychological Association (APA)
Capece, Daria& Verzella, Daniela& Fischietti, Mariafausta& Zazzeroni, Francesca& Alesse, Edoardo. 2012. Targeting Costimulatory Molecules to Improve Antitumor Immunity. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-508672
Modern Language Association (MLA)
Capece, Daria…[et al.]. Targeting Costimulatory Molecules to Improve Antitumor Immunity. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-508672
American Medical Association (AMA)
Capece, Daria& Verzella, Daniela& Fischietti, Mariafausta& Zazzeroni, Francesca& Alesse, Edoardo. Targeting Costimulatory Molecules to Improve Antitumor Immunity. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-508672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508672