MALDI-MS-Based Profiling of Serum Proteome : Detection of Changes Related to Progression of Cancer and Response to Anticancer Treatment
Joint Authors
Widłak, Piotr
Pietrowska, Monika
Source
International Journal of Proteomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Mass spectrometry-based analyses of the low-molecular-weight fraction of serum proteome allow identifying proteome profiles (signatures) that are potentially useful in detection and classification of cancer.
Several published studies have shown that multipeptide signatures selected in numerical tests have potential values for diagnostics of different types of cancer.
However due to apparent problems with standardization of methodological details, both experimental and computational, none of the proposed peptide signatures analyzed directly by MALDI/SELDI-ToF spectrometry has been approved for routine diagnostics.
Noteworthy, several components of proposed cancer signatures, especially those characteristic for advanced cancer, were identified as fragments of blood proteins involved in the acute phase and inflammatory response.
This indicated that among cancer biomarker candidates to be possibly identified by serum proteome profiling were rather those reflecting overall influence of a disease (and the therapy) upon the human organism, than products of cancer-specific genes.
Current paper focuses on changes in serum proteome that are related to response of patient’s organism to progressing malignancy and toxicity of anticancer treatment.
In addition, several methodological issues that affect robustness and interlaboratory reproducibility of MS-based serum proteome profiling are discussed.
American Psychological Association (APA)
Pietrowska, Monika& Widłak, Piotr. 2012. MALDI-MS-Based Profiling of Serum Proteome : Detection of Changes Related to Progression of Cancer and Response to Anticancer Treatment. International Journal of Proteomics،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-508689
Modern Language Association (MLA)
Pietrowska, Monika& Widłak, Piotr. MALDI-MS-Based Profiling of Serum Proteome : Detection of Changes Related to Progression of Cancer and Response to Anticancer Treatment. International Journal of Proteomics No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-508689
American Medical Association (AMA)
Pietrowska, Monika& Widłak, Piotr. MALDI-MS-Based Profiling of Serum Proteome : Detection of Changes Related to Progression of Cancer and Response to Anticancer Treatment. International Journal of Proteomics. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-508689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508689