Psychosis in Alzheimer's Disease in the National Alzheimer's Disease Coordinating Center Uniform Data Set : Clinical Correlates and Association with Apolipoprotein E
Joint Authors
DeMichele-Sweet, Mary Ann A.
Sweet, Robert A.
Lopez, Oscar L.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Approximately 50% of late-onset Alzheimer's disease (AD) patients develop psychosis (AD+P), a heritable phenotype associated with more rapid cognitive decline.
Prior studies conflict regarding whether apolipoprotein E (APOE) ϵ4 alleles are associated with AD+P, possibly due to small sample sizes, inconsistent diagnostic criteria, and different methodologies to assess psychosis.
We used the National Alzheimer's Coordinating Center Uniform Data Set to evaluate the largest uniformly characterized sample of AD+P subjects studied to date for the association of APOE ϵ4 genotype, along with other demographic and clinical variables.
Greater cognitive impairment and depressive symptoms were associated with AD+P, while the Caucasian race was protective.
Neither APOE ϵ4 carrier status nor allele number was associated with psychosis.
The AD+P phenotype is not associated with the APOE ϵ4 genotype.
AD+P may represent a useful phenotype for the discovery of non-APOE ϵ4 genetic variation contributing to the risk of AD.
American Psychological Association (APA)
DeMichele-Sweet, Mary Ann A.& Lopez, Oscar L.& Sweet, Robert A.. 2011. Psychosis in Alzheimer's Disease in the National Alzheimer's Disease Coordinating Center Uniform Data Set : Clinical Correlates and Association with Apolipoprotein E. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-508710
Modern Language Association (MLA)
DeMichele-Sweet, Mary Ann A.…[et al.]. Psychosis in Alzheimer's Disease in the National Alzheimer's Disease Coordinating Center Uniform Data Set : Clinical Correlates and Association with Apolipoprotein E. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-508710
American Medical Association (AMA)
DeMichele-Sweet, Mary Ann A.& Lopez, Oscar L.& Sweet, Robert A.. Psychosis in Alzheimer's Disease in the National Alzheimer's Disease Coordinating Center Uniform Data Set : Clinical Correlates and Association with Apolipoprotein E. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-508710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508710