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Genetics of Type 2 Diabetes : Insights into the Pathogenesis and Its Clinical Application
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
With rapidly increasing prevalence, diabetes has become one of the major causes of mortality worldwide.
According to the latest studies, genetic information makes substantial contributions towards the prediction of diabetes risk and individualized antidiabetic treatment.
To date, approximately 70 susceptibility genes have been identified as being associated with type 2 diabetes (T2D) at a genome-wide significant level (P<5×10-8).
However, all the genetic loci identified so far account for only about 10% of the overall heritability of T2D.
In addition, how these novel susceptibility loci correlate with the pathophysiology of the disease remains largely unknown.
This review covers the major genetic studies on the risk of T2D based on ethnicity and briefly discusses the potential mechanisms and clinical utility of the genetic information underlying T2D.
American Psychological Association (APA)
Sun, Xue& Yu, Weihui& Hu, Cheng. 2014. Genetics of Type 2 Diabetes : Insights into the Pathogenesis and Its Clinical Application. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-508714
Modern Language Association (MLA)
Sun, Xue…[et al.]. Genetics of Type 2 Diabetes : Insights into the Pathogenesis and Its Clinical Application. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-508714
American Medical Association (AMA)
Sun, Xue& Yu, Weihui& Hu, Cheng. Genetics of Type 2 Diabetes : Insights into the Pathogenesis and Its Clinical Application. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-508714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508714