Synthesis and Biological Evaluation of Novel γ-Alkylidene Butenolides
Joint Authors
Liu, Gai-Zhi
Guan, Yan-Bin
Wu, Ya
Liu, Hong-Min
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Three new series of 4-substituted-5-alkylidene-2,5-dihydrofuran-2-ones were synthesized.
The in vitro activity test results showed that some of them exhibited good antibacterial and cytotoxic activities.
Among them compound 5c showed the most potent antibacterial activity against Escherichia coli with the MIC value of 20.00 μg/mL.
Compound 9c showed good cytotoxic activity against Ec9706 cells with IC50 value of 19.39 μM, better than that of the reference compound fluorouracil (IC50=37.74 μM).
American Psychological Association (APA)
Liu, Gai-Zhi& Guan, Yan-Bin& Wu, Ya& Liu, Hong-Min. 2013. Synthesis and Biological Evaluation of Novel γ-Alkylidene Butenolides. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508716
Modern Language Association (MLA)
Liu, Gai-Zhi…[et al.]. Synthesis and Biological Evaluation of Novel γ-Alkylidene Butenolides. Journal of Chemistry No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-508716
American Medical Association (AMA)
Liu, Gai-Zhi& Guan, Yan-Bin& Wu, Ya& Liu, Hong-Min. Synthesis and Biological Evaluation of Novel γ-Alkylidene Butenolides. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-508716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508716
