![](/images/graphics-bg.png)
Intratumoral TLR-4 Agonist Injection Is Critical for Modulation of Tumor Microenvironment and Tumor Rejection
Joint Authors
Hinrichs, David
Souza, Ana Paula Duarte de
Smithey, Megan
Maito, Fabio Luiz Dal Moro
Pereira, Luciana
Bouwer, Archie
Bonorino, Cristina
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The tumor microenvironment shelters a complex network of mechanisms that enables local Immunosuppression to support tumor growth.
In this study we found that, B16F10 melanoma growth is inversely correlated with peritumoral infiltrate cell number and with cell numbers in draining lymph nodes.
Tumor growth ensued even when a foreign antigen was expressed by B16F10 cells in the presence of naïve specific CD8+ T cells.
Treatment with TLR agonists has shown to sometimes result in tumor regression, however, not always with long-lasting effects.
We compared the relevance of different injection regimens of lipopolysaccharide (LPS).
Tumor growth was arrested only by intratumoral LPS injection after the tumor was already established.
This result was accompanied by a dramatic change in DC activation inside the tumor.
Intratumoral LPS also enhanced antigen presentation and tumor-specific CD4+ T cell production of IFN-γ.
Injection of LPS before tumor challenge or codelivery of tumor cells and LPS did not have any effect on tumor progression.
Our results suggest that an efficient antitumor immune response leading to tumor regression can be achieved with proper TLR4 activation inside the tumor tissue, impacting the tumor microenvironment.
These findings are relevant for the design of treatment for patients with malignant melanomas.
American Psychological Association (APA)
Maito, Fabio Luiz Dal Moro& Souza, Ana Paula Duarte de& Pereira, Luciana& Smithey, Megan& Hinrichs, David& Bouwer, Archie…[et al.]. 2012. Intratumoral TLR-4 Agonist Injection Is Critical for Modulation of Tumor Microenvironment and Tumor Rejection. ISRN Immunology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-508730
Modern Language Association (MLA)
Maito, Fabio Luiz Dal Moro…[et al.]. Intratumoral TLR-4 Agonist Injection Is Critical for Modulation of Tumor Microenvironment and Tumor Rejection. ISRN Immunology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-508730
American Medical Association (AMA)
Maito, Fabio Luiz Dal Moro& Souza, Ana Paula Duarte de& Pereira, Luciana& Smithey, Megan& Hinrichs, David& Bouwer, Archie…[et al.]. Intratumoral TLR-4 Agonist Injection Is Critical for Modulation of Tumor Microenvironment and Tumor Rejection. ISRN Immunology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-508730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508730