The Genetics of PTPN1 and Obesity : Insights from Mouse Models of Tissue-Specific PTP1B Deficiency
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The protein tyrosine phosphatase PTP1B is a negative regulator of both insulin and leptin signaling and is involved in the control of glucose homeostasis and energy expenditure.
Due to its prominent role in regulating metabolism, PTP1B is a promising therapeutic target for the treatment of human obesity and type 2 diabetes.
The PTP1B protein is encoded by the PTPN1 gene on human chromosome 20q13, a region that shows linkage with insulin resistance, type 2 diabetes, and obesity in human populations.
In this paper, we summarize the genetics of the PTPN1 locus and associations with metabolic disease.
In addition, we discuss the tissue-specific functions of PTP1B as gleaned from genetic mouse models.
American Psychological Association (APA)
Tsou, Ryan C.& Bence, Kendra K.. 2012. The Genetics of PTPN1 and Obesity : Insights from Mouse Models of Tissue-Specific PTP1B Deficiency. Journal of Obesity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-508734
Modern Language Association (MLA)
Tsou, Ryan C.& Bence, Kendra K.. The Genetics of PTPN1 and Obesity : Insights from Mouse Models of Tissue-Specific PTP1B Deficiency. Journal of Obesity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-508734
American Medical Association (AMA)
Tsou, Ryan C.& Bence, Kendra K.. The Genetics of PTPN1 and Obesity : Insights from Mouse Models of Tissue-Specific PTP1B Deficiency. Journal of Obesity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-508734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508734
