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Efficacy and Safety of Echinacoside in a Rat Osteopenia Model
Joint Authors
Shen, Jinyang
Li, Fei
Yang, Yanan
Yang, Zhonglin
Zhu, Panpan
Zhang, Chunfeng
Yang, Xiaolin
Zou, Run
Li, Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study aimed to investigate the efficacy and safety of echinacoside (ECH) using an osteopenia rat model.
Forty-eight 6-month-old female Sprague-Dawley rats were randomly divided into one sham-operated group (SHAM) and five OVX (ovariectomized) subgroups: SHAM with vehicle 0.5% carboxymethylcellulose sodium (0.5% CMC-Na) and OVX with vehicle (OVX), OVX with 17β-estradiol (E2), and OVX with ECH of graded doses (ECH-L, ECH-M, and ECH-H).
The effects of ECH and E2 on serum biochemical parameters, bone mineral density (BMD), bone biomechanical properties, bone microarchitecture, and immunohistochemistry were examined, and safety assessments were also evaluated.
The results showed that ECH treatments improved total femur BMD, bone microarchitecture, and biomechanical properties and decreased serum marker levels in comparison to OVX group.
Moreover, ECH administration significantly increased osteoprotegerin (OPG) level, and decreased receptor activator of nuclear factor-κB ligand (RANKL) level in serum, as well as in proximal femur.
Importantly, ECH treatment ameliorated the lipid parameters without the overall incidences of adverse events of uterus and mammary gland compared to OVX and SHAM groups.
This study demonstrated that administration of ECH for 12 weeks can effectively and safely prevent OVX-induced osteoporosis in rats via increasing the OPG/RANKL ratio.
American Psychological Association (APA)
Yang, Xiaolin& Li, Fei& Yang, Yanan& Shen, Jinyang& Zou, Run& Zhu, Panpan…[et al.]. 2013. Efficacy and Safety of Echinacoside in a Rat Osteopenia Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-508738
Modern Language Association (MLA)
Yang, Xiaolin…[et al.]. Efficacy and Safety of Echinacoside in a Rat Osteopenia Model. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-508738
American Medical Association (AMA)
Yang, Xiaolin& Li, Fei& Yang, Yanan& Shen, Jinyang& Zou, Run& Zhu, Panpan…[et al.]. Efficacy and Safety of Echinacoside in a Rat Osteopenia Model. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-508738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508738