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Bicuspid Aortic Valve and Thoracic Aortic Aneurysm : Three Patient Populations, Two Disease Phenotypes, and One Shared Genotype
Author
Source
Cardiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Bicuspid aortic valve (BAV) and thoracic aortic aneurysm (TAA) are two discrete cardiovascular phenotypes characterized by latent progressive disease states.
There is a clear association between BAV and TAA; however the nature and extent of this relationship is unclear.
There are both distinct and overlapping developmental pathways that have been established to contribute to the formation of the aortic valve and the aortic root, and the mature anatomy of these different tissue types is intimately intertwined.
Likewise, human genetics studies have established apparently separate and common contributions to these clinical phenotypes, suggesting complex inheritance and a shared genetic basis and translating 3 patient populations, namely, BAV, TAA, or both, into a common but diverse etiology.
A better understanding of the BAV-TAA association will provide an opportunity to leverage molecular information to modify clinical care through more sophisticated diagnostic testing, improved counseling, and ultimately new pharmacologic therapies.
American Psychological Association (APA)
Hinton, Robert B.. 2012. Bicuspid Aortic Valve and Thoracic Aortic Aneurysm : Three Patient Populations, Two Disease Phenotypes, and One Shared Genotype. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-508744
Modern Language Association (MLA)
Hinton, Robert B.. Bicuspid Aortic Valve and Thoracic Aortic Aneurysm : Three Patient Populations, Two Disease Phenotypes, and One Shared Genotype. Cardiology Research and Practice No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-508744
American Medical Association (AMA)
Hinton, Robert B.. Bicuspid Aortic Valve and Thoracic Aortic Aneurysm : Three Patient Populations, Two Disease Phenotypes, and One Shared Genotype. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-508744
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508744